Saliva contains proteolytic enzymes which acts as a major enzymatic barrier to the permeation of drug through buccal tissues. Bioadhesive polymers, power point presentation, slide. Muco adhesion free download as powerpoint presentation. Mucoadhesive drug delivery systems prolong the residence time of the dosage form at the site of application or absorption. Mucoadhesive drug delivery system authorstream presentation. Since the early 1980,the concept of mucoadhesion has gained considerable interest in pharmaceutical technology. The use of mucoadhesive drug delivery system with enzyme inhibitor had been developed to overcome the barrier in the peptide and protein delivery. Formulation and evaluation of mucoadhesive drug delivery. The recent trend aimed at the development of mucomimetics substrates to formulate in vitro mucus or mucosae model for. Review on mucoadhesive drug delivery system with special. Dear sir, please send me the ppt related to mucoadhesive drug. Mucoadhesive drug delivery systems pubmed central pmc.
Mucoadhesion is commonly defined as the adhesion between two materials, at least one of which is a mucosal surface. Mucoadhesive drug delivery system is a part of controlled delivery system. Mucoadhesive dosage forms may be designed to enable prolonged retention at the site of application. Application of dosage forms to mucosal surfaces may be of benefit to drug molecules not amenable to the oral route, such as those that undergo acid degradation or extensive firstpass metabolism. Pdf buccal tablet as a promising mucoadhesive drug delivery. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. Mucoadhesion is define as drug delivery system that utilize the property of bioadhesion of certain watersoluble polymers which become adhesive on hydration and hence can be used for targeting a drug to a particular region of the body for an extended period of time. Introduction to mucoadhesive drug delivery youtube. In the last two decades, mucoadhesion has shown renewed interest for prolonging the residence time of mucoadhesive dosage forms through various mucosal. The process of mucoadhesion involving a polymeric drug delivery system is a complex one that includes processes such as wetting, adsorption and interpenetration of polymer chains. Formulation and evaluation of mucoadhesive drug delivery systems free download as powerpoint presentation.
Thus, the mechanism of mucoadhesion is generally divided in two steps, the contact stage and the consolida tion stage figure 1. Innovative methods in mucoadhesion research full v3 formatted. Electronic theory is based on the premise that both mucoadhesive and biological materials possess opposing electrical charges. Over the past few decades, mucosal drug delivery has received a great deal of attention. Pdf novel paradigms in mucoadhesive drug delivery system.